A revolutionary antimicrobial alternative to conventional antibiotics

A team of researchers at the Centre for Advanced Macromolecular Design in Sidney reported the synthesis of an antimicrobial in the form of single-chain polymeric nanoparticles (SCPNs), that shows excellent activity against Gram-negative bacteria, such as Pseudomonas aeruginosa, even at micromolar concentrations, e.g. 1.4 μM (effectiveness ≥99.99%). The novel antibacterial comprises oligoethylene glycol (OEG), SCPNs and amine groups. The balance of these three components provides a system producing a better response than many other antibiotics, with a higher therapeutic index and hence better biocompatibility. Moreover, its bactericidal effectiveness is ≥99.99% in an hour. The researchers are now continuing the study with experiments on animals. (Source Infectious Diseases)